Wednesday, November 25, 2009

US Patent 7622437 - Nanoparticle blood clot agent

This patent from the University of Illinois teaches a phospholipid nanoparticle composition which enhances certain proteins ability to trigger blood coagulation. Claim 1 reads:

1. A method for controlling bleeding in a human or animal patient, said method comprising the step of administering, in an amount effective to control bleeding in said patient a composition comprising nanoscale particles comprising tissue factor or recombinant tissue factor, a membrane scaffold protein and phospholipid, wherein the phospholipid comprises a net-negatively charged phospholipid, and wherein said nanoscale particles are attached to a solid support, whereby bleeding in said patient is controlled.