Tuesday, May 24, 2011

US Patent 7947454 - Polynucleotide analysis with nanopores


This patent is based on a collaboration between Harvard, the University of California, and Agilent Technologies and includes same basic claims toward sequencing RNA and DNA using nanopores. Claim 1 reads:

1. A method for analyzing a target polynucleotide, comprising the steps of:

(a) introducing the target polynucleotide to a nanopore analysis system comprising a nanopore aperture;

(b) allowing the target polynucleotide to move with respect to the nanopore aperture to produce a signal at a rate of 350-2000 Hz; and

(c) monitoring the signal corresponding to the movement of the target polynucleotide with respect to the nanopore aperture, thereby analyzing the target polynucleotide.

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